Evidence map›Paper›PMID 41789880›Full record

ArticleeLife2026

Progressive mural cell deficiencies across the lifespan in a

Merry Faye E Graff, Emma E M Heeg, David A Elliott, Sarah J Childs

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Merry Faye E GraffAlberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0009-0006-6861-5759
Emma E M HeegAlberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0009-0002-0879-133X
David A ElliottHotchkiss Brain Institute Advanced Microscopy Platform, University of Calgary, Calgary, Canada.
Sarah J ChildsAlberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0003-2261-580X

Funding

CIHR PJT-183631
6 · The paper itself

Abstract

Cerebral small vessel disease (SVD) is a leading cause of stroke and dementia and yet is often an incidental finding in aged patients due to the inaccessibility of brain vasculature to imaging. Animal models are important for modelling the development and progression of SVD across the lifespan. In humans, reduced

Indexed as

Cerebral Small Vessel DiseasesForkhead Transcription FactorsPericytesZebrafish ProteinsAnimalsBrainDisease Models, AnimalZebrafishForkhead Transcription FactorsZebrafish Proteinsblood vesseldevelopmental biologymural cellspericytessmall vessel diseasezebrafish

Identifiers

PMID41789880
PMCPMC12965718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.