Evidence map›Paper›PMID 41789867›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Region-specific ups and downs in mitochondrial numerical densities during Alzheimer's disease progression: A pilot study in human brains.

Anna-Lena Balsliemke, Barbara Ahlemeyer, Eugen Schmidl, Till Acker, Anne Schänzer, Eveline Baumgart-Vogt

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna-Lena BalsliemkeInstitute for Anatomy and Cell Biology, Division of Medical Cell Biology, Justus-Liebig University, Gießen, Germany.ORCID 0009-0000-2196-4800
Barbara AhlemeyerInstitute for Anatomy and Cell Biology, Division of Medical Cell Biology, Justus-Liebig University, Gießen, Germany.ORCID 0009-0005-1278-8418
Eugen SchmidlInstitute for Anatomy and Cell Biology, Division of Medical Cell Biology, Justus-Liebig University, Gießen, Germany.ORCID 0009-0003-6835-6716
Till AckerInstitute of Neuropathology, Justus-Liebig University, Gießen, Germany.ORCID 0000-0001-6357-7227
Anne SchänzerInstitute of Neuropathology, Justus-Liebig University, Gießen, Germany.
Eveline Baumgart-VogtInstitute for Anatomy and Cell Biology, Division of Medical Cell Biology, Justus-Liebig University, Gießen, Germany.ORCID 0000-0002-8265-3763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundMitochondrial dysfunction is an important pathogenic factor in Alzheimer´s disease (AD) progression. Most studies analysed disturbances in the mitochondrial metabolism and oxidative stress or focussed on mitochondrial dynamics such as mitochondrial trafficking, fusion-fission and mitophagy.ObjectiveVery limited data exist regarding changes in the mitochondrial numerical density at different levels of AD neuropathologic changes (ADNC) in

Indexed as

Alzheimer DiseaseBrainMitochondriaAgedAged, 80 and overDisease ProgressionFemaleHumansMaleNeuronsPilot ProjectsTauopathiesAlzheimer's diseaseamyloid-βenergy metabolism/oxidative stressfatty acidshippocampusimmunocytochemistrylipidmetabolismmitochondriamitochondrial numerical densityneurofibrillary tanglestauopathies

Identifiers

PMID41789867
PMCPMC12982581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.