Evidence map›Paper›PMID 41789792›Full record

Trial reportJournal of periodontology2026

A randomized controlled trial of home-applied dual-light photodynamic therapy during supportive periodontal care (HOPE-CP study).

Saila Pakarinen, Hannamari Välimaa, Anna M Heikkinen, Marja Noponen, Heikki Alapulli, Riitta K T Saarela, Taina Tervahartiala, Ismo T Räisänen, Timo Sorsa, Dimitra Sakellari and 1 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07763431 (Efficacy of Home-Use Dual-Light Antimicrobial Photodynamic Therapy as an Adjunct to Supportive Peri-Implant Care in Patients With Peri-Implant Mucositis Around Screw-Retained Full-Arch Implant-Supported Prostheses), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07763431 nanot yet recruitingnot on this map

Efficacy of Home-Use Dual-Light Antimicrobial Photodynamic Therapy as an Adjunct to Supportive Peri-Implant Care in Patients With Peri-Implant Mucositis Around Screw-Retained Full-Arch Implant-Supported Prostheses: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Medicine and Pharmacy at Ho Chi Minh CityRan2026 to 2027Enrolled24ConditionsPeri Implant Mucositis, Dental Implant Rehabilitation, Prosthesis and Implant Dentistry, Implant Supported ProsthesisArmsDual-light antibacterial photodynamic therapy, Supportive peri-implant care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saila PakarinenSchool of Rehabilitation and Examination, Metropolia University of Applied Sciences, Helsinki, Finland.
Hannamari VälimaaDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, Department of Oral Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Anna M HeikkinenFaculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
Marja NoponenSocial Services, Healthcare and Rescue Services Division, Oral Health Care, Helsinki, Finland.
Heikki AlapulliDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, Department of Oral Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Riitta K T SaarelaSocial Services, Healthcare and Rescue Services Division, Oral Health Care, Helsinki, Finland.
Taina TervahartialaDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, Department of Oral Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Ismo T RäisänenDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, Department of Oral Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, Department of Oral Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
Dimitra SakellariDepartment of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Tommi PätiläDepartment of Congenital Heart Surgery and Organ Transplantation, New Children's Hospital, University of Helsinki, Helsinki, Finland.

Funding

Finnish Dental Association Apollonia, and Karolinska Institutions ApolloniaHelsinki and Uusimaa Hospital District (HUS) TYH2018229Helsinki and Uusimaa Hospital District (HUS) TYH2019319Helsinki and Uusimaa Hospital District (HUS) TYH2022225Helsinki and Uusimaa Hospital District (HUS) Y1014SL017Helsinki and Uusimaa Hospital District (HUS) Y1014SL018Helsinki and Uusimaa Hospital District (HUS) Y1014SULE1Helsinki and Uusimaa Hospital District (HUS) Y2114SU010Koite Health Ltd
6 · The paper itself

Abstract

backgroundPeriodontitis is a common, chronic inflammatory disease that relies heavily on effective daily oral hygiene for long-term control. Light-based therapies have demonstrated strong antibacterial potential; however, their effectiveness in regular home use remains unexplored.

methodsTwo hundred stage I-III periodontitis maintenance patients were randomized for supportive periodontal care (SPC) or SPC combined with adjunct home-applied dual-light therapy. Bleeding on probing (BOP), visible plaque index (VPI), and the number of sites with ≥4 mm periodontal probing depth (PPD) were measured at the baseline, at 3 and 6 months.

resultsOf the 200 randomized patients, 184 completed all visits. At baseline, the groups were similar for BOP, VPI, and pocket depth. At 3 and 6 months, adjunctive dual-light therapy achieved lower BOP (12.6 ±  0.7% and 12.0 ±  0.8%) than SPC alone (17.8 ±  0.8% and 17.3 ±  1.0%); p < 0.0001 and p = 0.0002 and lower VPI (8.5 ± 0.7% and 9.7 ± 0.8%) vs. (13.3 ± 0.8% and 14.2 ± 1.0%); p < 0.0005 and 0.0142. The dual-light group also had fewer sites with PPD ≥ 4 mm (5.6 ± 0.7 and 5.3 ± 0.6) vs. (7.6 ± 1.2 and 7.8 ± 0.9); p = 0.02 and p = 0.02.

conclusionRegularly home-applied dual-light therapy may represent a promising addition to existing home-care strategies and a potential advance in adjunctive periodontal maintenance. PLAIN LANGUAGE SUMMARY: Periodontitis is a common disease that damages the tissues supporting the teeth. Daily brushing and cleaning between the teeth are essential, but even with good routines, people can still develop plaque and gum inflammation. Light-based treatments are known to eliminate plaque bacteria effectively, but until now, they have mostly been used in dental offices, and their potential for home use has not been tested. In the HOPE-CP study, we enrolled 200 adults with periodontitis to receive routine supportive periodontal care. Half of them were randomized to use a light-based antibacterial device to support their daily oral hygiene at home. After 3 and 6 months, those using the device had less gum bleeding, less visible plaque, and fewer sites with deeper periodontal pockets than those who used routine care alone. These results show that using a daily antibacterial light treatment at home may help people better control inflammation and maintain healthier gums between dental visits.

Indexed as

Chronic PeriodontitisHome Care ServicesPhotochemotherapySelf CareAdultAgedCombined Modality TherapyDental Plaque IndexDental ScalingFemaleFollow-Up StudiesGingival HemorrhageHumansMaleMiddle AgedOral HygienePhotosensitizing AgentsRiboflavinantibacterial photodynamic therapy (aPDT)dental devices, home caredual‐light photodynamic therapyperiodontitisphotobiomodulation therapy (PBMT)supportive periodontal care (SPC)

Identifiers

PMID41789792
PMCPMC13169474

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.