ReviewMolecular medicine reports2026
Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review).
Review in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Glycyrrhizin Ameliorates Learning and Memory Impairment via Inhibition of Neuroinflammation in an Alzheimer's Disease Mouse Model SAMP8.International journal of molecular sciences · 2026Article
- Article
- Dietary glycyrrhizic acid improves growth performance and modulates upper respiratory microbiota in weaned piglets.BMC veterinary research · 2026Article
- Therapeutic Effects of Glycyrrhizic Acid on Dry Eye Disease: Targeting Pyroptosis, Oxidative Stress, and Epithelial Barrier Dysfunction.International journal of molecular sciences · 2026Article
- Glycyrrhizin (GLY) and glycyrrhetinic acid (GA) as potential multi-target antimicrobials: mechanisms, biofilm disruption, and synergy against drug-resistant pathogens.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycyrrhizic acid (GL), a natural extract derived from licorice, has shown notable therapeutic potential across various diseases through complex mechanisms involving key signaling pathways. The present review systematically summarized the primary biological actions of GL, highlighting its role as an inhibitor of high‑mobility group box‑1 and regulator of multiple notable pathways, including the nuclear factor‑κB, phosphoinositide 3‑kinase/protein kinase B, mitogen‑activated protein kinase, Janus kinase/signal transducer and activator of transcription and pyroptosis‑related pathways. GL effectively modulates innate and adaptive immune responses, reduces inflammation and exhibits protective effects against liver injury. In oncology, GL has demonstrated anti‑proliferative and pro‑apoptotic effects by interacting with the tumor microenvironment, suppressing angiogenesis and enhancing chemotherapeutic efficacy as an adjuvant therapy. By synthesizing previous research advancements that elucidate the multifaceted biological mechanisms of GL, the present review aimed to provide a comprehensive foundation for future translational research.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.