Evidence map›Paper›PMID 41789580›Full record

ArticleMolecular medicine reports2026

Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating of connexin 43 in offspring rats.

Yan Wen, Yao Yuan, Haigang Zhang, Ya Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yan WenDepartment of Pharmacology, College of Pharmacy, Army Medical University, Chongqing 400038, P.R. China.
Yao YuanDepartment of Pharmacology, College of Pharmacy, Army Medical University, Chongqing 400038, P.R. China.
Haigang ZhangDepartment of Pharmacology, College of Pharmacy, Army Medical University, Chongqing 400038, P.R. China.
Ya LiuDepartment of Pharmacology, College of Pharmacy, Army Medical University, Chongqing 400038, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigated the role of connexin 43 (Cx43) in mediating prenatal inflammation‑induced cardiac fibrosis in offspring, specifically exploring its dynamic regulation with autophagy and DNA methylation pathways. Pregnant Sprague‑Dawley rats received intraperitoneal injections of saline (control) or lipopolysaccharide (LPS, 0.79 mg/kg) on gestational days 8, 10 and 12. Offspring were sacrificed at 8 and 16 weeks postpartum. Myocardial tissues were subjected to histopathological examination and molecular analysis. Prenatal LPS exposure consistently induced significant cardiac fibrosis in the offspring. Reverse transcription‑quantitative PCR revealed that mRNA levels of

Indexed as

Connexin 43LipopolysaccharidesMyocardiumPrenatal Exposure Delayed EffectsAnimalsAutophagyDNA (Cytosine-5-)-Methyltransferase 1DNA MethylationFemaleFibroblastsFibrosisMicrotubule-Associated ProteinsPregnancyRatsRats, Sprague-DawleyAnxa3 protein, ratConnexin 43DNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, ratGja1 protein, ratLipopolysaccharidesMicrotubule-Associated Proteinsautophagycardiac fibrosisconnexin 43DNA methylationintrauterine inflammation

Identifiers

PMID41789580
PMCPMC12957900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.