ArticleJournal of veterinary internal medicine2026
Evaluation of platelet surface-associated immunoglobulin positivity and its association with hematologic findings and vector-borne pathogens in thrombocytopenic dogs.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative efficacy of once-daily versus twice-daily doxycycline regimens in dogs naturally infected withVeterinary and animal science · 2026Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet surface-associated immunoglobulin (PSAIG) occurs in thrombocytopenic dogs with vector-borne diseases and immune thrombocytopenia (ITP) and may be associated with thrombocytopenia severity and inflammatory markers, including neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios (NLR, PLR). HYPOTHESIS/
objectivesAssess associations between PSAIG positivity, hematologic parameters, thrombocytopenia severity, and vector-borne status in thrombocytopenic dogs. ANIMALS: Sixty-nine client-owned thrombocytopenic dogs (<200 × 103/μL) were enrolled between June 2022 and June 2023.
methodsDogs were prospectively enrolled. Platelet surface-associated immunoglobulin was measured using flow cytometry. Vector-borne pathogens were assessed by serology (Ehrlichia spp., Anaplasma spp., Borrelia burgdorferi, Dirofilaria immitis) and PCR for Ehrlichia canis. Hematologic parameters were compared between PSAIG groups (Mann-Whitney U), and associations tested by univariable logistic regression.
resultsDogs positive for PSAIG (n = 16) had lower median automated platelet counts (16.5 × 103/μL; interquartile range [IQR]: 8.25-40.75) than PSAIG-negative dogs (n = 53; 64 × 103/μL; IQR: 25.0-92.5; P = .001), with similarly lower manual platelet counts (48 × 103/μL; IQR: 20-86 vs 96 × 103/μL; IQR: 55-138; P = .01) and automated PLR (7.14; IQR: 3.30-15.28 vs 21.82; IQR: 9.42-38.99; P = .01). In logistic regression, PSAIG positivity was associated with lower platelet counts and automated PLR, E. canis PCR positivity, and Anaplasma seropositivity, with the strongest association for concurrent E. canis PCR and Anaplasma seropositivity (odds ratio [OR]; 15.3; 95% confidence interval [CI]: 2.69-86.99; P = .002). CONCLUSIONS AND CLINICAL IMPORTANCE: Lower platelet counts and automated PLR were associated with PSAIG positivity in thrombocytopenic dogs. Associations between PSAIG, E. canis infection, and co-exposure to Anaplasma spp. support immune-mediated platelet destruction in infected dogs.
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