Evidence map›Paper›PMID 41789548›Full record

ArticleJournal of veterinary internal medicine2026

Sequential measurement of serum amyloid A concentrations in ill hospitalized neonatal foals.

Astrid J van den Brom-Spierenburg, Esther W Siegers, Cornélie M Westermann, Johannes C M Vernooij, Marianne M Sloet van Oldruitenborgh-Oosterbaan, Mathijs J P Theelen

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Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Astrid J van den Brom-SpierenburgDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Esther W SiegersDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Cornélie M WestermannDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Johannes C M VernooijDepartment Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Marianne M Sloet van Oldruitenborgh-OosterbaanDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Mathijs J P TheelenDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn hospitalized foals, limited data are available on the utility of sequential measurement of SAA concentrations and the value of these data in a clinical setting. HYPOTHESIS/

objectivesTo determine serum amyloid A (SAA) concentrations in ill neonatal foals at multiple timepoints during hospitalization, and to evaluate a potential association with systemic inflammatory response syndrome (SIRS) status, blood culture (BC) result, and survival. ANIMALS: Hospitalized ill foals (n = 90, ≤ 14 days).

methodsIn this retrospective study, foals were classified based on SIRS criteria: "SIRS" or "NonSIRS," BC results, and survival. Serum amyloid A concentrations on admission (ADM), day 1 (D1) and day 2 (D2) were compared within and between groups, using nonparametric tests. Results are presented as median (IQR) (effect size; 95% CI).

resultsSerum amyloid A concentrations were higher in SIRS than in NonSIRS foals both on ADM (401 mg/L (99; 855) vs 67 mg/L (23; 685), [ES 129, 95% CI, 15-385]), and on D1 (836 mg/L (616; 1240) vs 212 mg/L (69; 890), [ES 501, 95% CI, 121-724]). On D2, but not on ADM, foals with a positive BC had higher SAA (1244 mg/L (757; 2004)) than BC negative foals (153 mg/L (57; 695), [ES 1002; 95% CI, 282-1418]). On D1, but not on ADM, SAA was higher in non-survivors (729 mg/L (469; 1347) than in survivors (323 mg/L (75; 889), [ES 373; 95% CI, 28-651]). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum amyloid A measurements on D1 and D2 of hospitalization likely reflect both the severity of disease and response to initial treatment. Repeated SAA measurements during hospitalization can aid clinicians in determining severity of disease and can be useful as a prognosticator in ill neonatal foals.

Indexed as

Horse DiseasesSerum Amyloid A ProteinSystemic Inflammatory Response SyndromeAnimalsAnimals, NewbornFemaleHorsesMaleRetrospective StudiesSerum Amyloid A Proteinacute phase proteinblood cultureblood stream infectionneonatologyprognosticatorSAAsepsisSIRS

Identifiers

PMID41789548
PMCPMC12963963

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