Evidence map›Paper›PMID 41789468›Full record

ArticlePerfusion2026

Post-operative oxygen delivery and delirium after cardiac surgery with cardiopulmonary bypass: A multisite retrospective cohort study of 1,690 patients.

Elijah Christensen, Victoria Kennerley, George Justison, David J Douin, Jack Pattee, Joseph C Cleveland, Thomas Brett Reece, Jessica Rove, Jordan R H Hoffman, Michael T Cain and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elijah ChristensenDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Victoria KennerleyDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
George JustisonDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
David J DouinDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Jack PatteeDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Joseph C ClevelandDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Thomas Brett ReeceDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Jessica RoveDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Jordan R H HoffmanDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Michael T CainDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Nicholas TemanDepartment of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Benjamin AbramsDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Adit A GindeDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.
Nathan ClendenenDepartment of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-0091-6524

Funding

Optimizing pulsatility during cardiopulmonary bypass to reduce acute kidney injuryK23HL151882 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CLENDENEN, NATHAN · 2020 to 2024
$906k
Restoring Endothelial Function After Traumatic Injury to Reduce ARDS and Multi-Organ DysfunctionK23HL165107 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David J. Douin · 2023 to 2026
$759k
NHLBI NIH HHS K23 HL151882NHLBI NIH HHS K23 HL165107
6 · The paper itself

Abstract

IntroductionDelirium is a common, distressing, and dangerous complication after cardiac surgery with cardiopulmonary bypass (CPB) with few modifiable risk factors. This study aims to determine the association between post-operative oxygen delivery (DO2i) and the risk of delirium and assess the critical threshold for DO2i associated with delirium risk after surgery.MethodsThis study is a multi-site retrospective cohort study with 1690 patients undergoing elective cardiac surgery with CPB who had multiple cardiac output measurements with a pulmonary artery catheter and arterial blood gas analyses.ResultsThe cohort of 1690 patients analyzed included 185 patients diagnosed with delirium within 7 days of surgery (11%). Patients with delirium had a lower post-operative DO2i (mean difference of 26 ml/min/m

Indexed as

agingcardiac surgerycardiopulmonary bypassdeliriumoxygen delivery

Identifiers

PMID41789468
PMCPMC13390545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.