ArticleCase reports in oncology
Brain Metastasis in Nasopharyngeal Carcinoma: A Case Report.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Introduction: Nasopharyngeal carcinoma (NPC) is endemic in Southeast Asia. Despite the close proximity of the nasopharynx to the brain, true brain metastasis is rarely observed in NPC. Case Presentation: We present an interesting case of NPC with brain metastasis which to our knowledge is the first case reported in Southeast Asia. The patient was asymptomatic, and brain metastasis was detected during surveillance PET scan. He underwent craniectomy and excision of brain metastasis followed by Gamma Knife to the tumour cavity and remains well 2 years post resection. Conclusion: We explore several possible hypotheses for the rarity of this phenomenon with the aid of the seed and soil theory including a new concept of (i) organ negative tropism, (ii) effective and good local regional control, and (iii) the inability of NPC to penetrate the blood-brain barrier and overcome the brain immune microenvironment.
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