Evidence map›Paper›PMID 41789397›Full record

ArticleFrontiers in oncology2025

ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC.

Grania Christyani, Chenghui Cai, Yening Feng, Hyorin Lee, Xinyi Tu, Chao Zhang, Zhenkun Lou, Wootae Kim

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Grania ChristyaniDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
Chenghui CaiCollege of Biology, Hunan University, Changsha, China.
Yening FengDepartment of Oncology, Mayo Clinic, Rochester, MN, United States.
Hyorin LeeDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
Xinyi TuDepartment of Oncology, Mayo Clinic, Rochester, MN, United States.
Chao ZhangDepartment of Oncology, Mayo Clinic, Rochester, MN, United States.
Zhenkun LouDepartment of Oncology, Mayo Clinic, Rochester, MN, United States.
Wootae KimDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability. Human ZFP161 activates

Indexed as

c-MYCc-MYC downstream pathwaytumor developmentZFP161zinc finger protein

Identifiers

PMID41789397
PMCPMC12956533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.