Evidence map›Paper›PMID 41789354›Full record

ArticleChemical science2026

Triple threat bismuth peptide imaging in cells.

Saan Voss, Clinton J Kidman, Liam D Adair, Samuel O Nitschke, Pramsak Patawanich, Terry Koh, Ani T Baker, Daryl L Howard, Elizabeth J New, Hugh H Harris and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Bismuth Bicycles.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saan VossResearch School of Chemistry, College of Science and Medicine, Australian National University Canberra ACT 2601 Australia christoph.nitsche@anu.edu.au.ORCID https://orcid.org/0000-0002-0108-0888
Clinton J KidmanDiscipline of Chemistry, The University of Adelaide North Terrace Adelaide SA 5005 Australia hugh.harris@adelaide.edu.au.ORCID https://orcid.org/0000-0003-3408-1171
Liam D AdairSchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.ORCID https://orcid.org/0000-0002-9527-4869
Samuel O NitschkeSchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.ORCID https://orcid.org/0000-0002-4455-2056
Pramsak PatawanichSchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.
Terry KohDiscipline of Chemistry, The University of Adelaide North Terrace Adelaide SA 5005 Australia hugh.harris@adelaide.edu.au.ORCID https://orcid.org/0000-0002-3609-0891
Ani T BakerDiscipline of Chemistry, The University of Adelaide North Terrace Adelaide SA 5005 Australia hugh.harris@adelaide.edu.au.ORCID https://orcid.org/0000-0002-1008-6384
Daryl L HowardAustralian Synchrotron, ANSTO 800 Blackburn Road Clayton VIC 3168 Australia.ORCID https://orcid.org/0000-0001-6071-2382
Elizabeth J NewSchool of Chemistry, The University of Sydney Sydney NSW 2006 Australia.ORCID https://orcid.org/0000-0002-2310-254X
Hugh H HarrisDiscipline of Chemistry, The University of Adelaide North Terrace Adelaide SA 5005 Australia hugh.harris@adelaide.edu.au.ORCID https://orcid.org/0000-0002-3472-8628
Christoph NitscheResearch School of Chemistry, College of Science and Medicine, Australian National University Canberra ACT 2601 Australia christoph.nitsche@anu.edu.au.ORCID https://orcid.org/0000-0002-3704-2699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bismuth peptides are emerging as a novel class of pharmaceutical agents. While cell-penetrating bismuth peptides have been reported recently, their detailed cellular interactions and stability remain poorly understood, and therefore new methods are required to visualise these peptides within cells. In this study, we synthesised cell-penetrating bismuth peptides conjugated to various fluorescent dyes (naphthalimide, coumarin, rhodamine B) and their brominated analogues, and investigated their cellular uptake in SKOV-3 cells using X-ray fluorescence microscopy (XFM) for bismuth and bromine, alongside optical fluorescence microscopy. Co-localisation of bromine, bismuth and the fluorescent dyes within the cytosol and cellular compartments indicates that the bismuth-peptide conjugates can enter cells intact. Among the three fluorescent dyes tested, naphthalimide and its brominated derivative were the most robust for multimodal imaging.

Identifiers

PMID41789354
PMCPMC12959375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.