Evidence map›Paper›PMID 41789265›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Transcriptome-based maturation assessment revealed pro-maturation transcription factors of cardiomyocytes.

Nawin Chanthra, Sean Murphy, Matthew Miyamoto, Nanami Masuyama, Nozomu Yachie, Chulan Kwon, Hideki Uosaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nawin ChanthraDivision of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Sean MurphyDivision of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Matthew MiyamotoDivision of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Nanami MasuyamaSchool of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, The University of British Columbia, Vancouver, Vancouver, BC, Canada.
Nozomu YachieSchool of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, The University of British Columbia, Vancouver, Vancouver, BC, Canada.
Chulan KwonDivision of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Hideki UosakiDivision of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.

Funding

Targeting Dysregulated Maturation Program in PSC-CardiomyocytesR01HL171205 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon · 2024 to 2026
$2.2M
American Heart Association-American Stroke Association 23TPA1058685NHLBI NIH HHS R01 HL171205
6 · The paper itself

Abstract

Induced pluripotent stem cell-derived cardiomyocytes have shown promise to be an essential tool for studying genetic cardiac diseases. However, their limited maturity remains a barrier to reaching their full potential. Many have challenged this problem; however, it is difficult to compare the results because the parameters for cardiomyocyte maturation are diverse, mostly relying on physiological experiments that display significant lab-to-lab variations and are labor-intensive, and are not comparable to maturing cardiomyocytes

Indexed as

cardiomyocytesERRαmaturationPGC1pluripotent stem cellstranscriptional factors

Identifiers

PMID41789265
PMCPMC12957250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.