ArticleAnnals of medicine and surgery (2012)2026
Global research trends in diagnostic biomarkers for colorectal cancer: a bibliometric and visualization analysis.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biological and Targeted Therapies in the Multidisciplinary Management of Gastrointestinal Cancers.Cancers · 2026Review
- Genetic Insights into Interleukin-13 Polymorphisms in Colorectal Cancer Risk and Progression.Cancer genomics & proteomicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) ranks as the third most prevalent malignancy worldwide, yet early detection rates remain suboptimal. Diagnostic biomarkers hold significant promise for improving early CRC detection. This study conducts a bibliometric and visualization analysis to elucidate global research trends in diagnostic biomarkers for CRC. Methods: A dataset of 255 publications was extracted from the Web of Science Core Collection (WoSCC) spanning from 1 January 2014 to 10 September 2024. CiteSpace, VOSviewer, and Excel were employed for comprehensive analysis of authorship patterns, journal distribution, institutional contributions, geographic focus, keyword co-occurrence, and citation networks. Results: Publication volumes demonstrated an initial upward trajectory, peaking in 2021 before a slight decline. China emerged as the leading contributor, followed by Egypt, Iran, and the United States, with the Egyptian Knowledge Bank identified as the most prolific institution. Keyword analysis revealed concentrated research interests in Colorectal Cancer, Genetic Markers, Long Non-Coding RNAs (lncRNAs), Proteins, DNA Methylation, and MicroRNAs. Conclusion: Genomic, proteomic, and non-coding RNA biomarkers represent the primary research frontiers in CRC diagnostics. Future investigations should prioritize multi-institutional cohort studies and integrated multi-omics approaches to validate and refine biomarkers for clinical implementation in early CRC screening programs.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.