ArticleFrontiers in immunology2026
Kinetics of antimalarial antibodies in children with common haemoglobinopathies in a Tanzanian population.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Haemoglobin gene mutations have long been associated with protection against malaria, as evidenced by the concordant geographic distribution of these mutations with malaria parasite prevalence and by the reduced risk of severe disease among individuals carrying thalassaemia or sickle cell trait alleles. However, the mechanisms underlying this protection remain poorly understood. Although the precise correlates of immunity to malaria are still debated, antibody-mediated responses are widely considered to play a critical role. In this study, we investigated changes in putatively protective anti-malarial antibody titres in relation to age, malaria infection, and protection in Tanzanian children with and without α Methods: Antibody responses were quantified using a multiplex assay targeting sporozoite antigens (CSP), merozoite antigens (AMA1, MSP1 Results: In age-adjusted analyses, antibody levels to MSP3 and Group B PfEMP1 exhibited opposing associations with inherited red blood cell disorders: responses were negatively associated with α Conclusion: These findings suggest that sickle cell trait may modulate PfEMP1 expression, thereby weakening the adhesion of
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