SynthesisFrontiers in immunology2026
Structural and temporal dynamics of nano-based therapies in ulcerative colitis: history, hotspots, and emerging trends.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- From nutritional intervention to immune modulation: a multi-database bibliometric and topic modeling study of vitamin D in inflammatory bowel disease.Frontiers in immunology · 2026Pooled it
- MASLD and sarcopenia research (2012-2025): a multi-database bibliometric analysis.Frontiers in nutrition · 2026Pooled it
- The evolving landscape ofFrontiers in immunology · 2026Pooled it
- Current landscape and emerging trends of PD-1/PD-L1 research in prostate cancer: A data-driven atlas from multidatabase integration.Human vaccines & immunotherapeutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nanomaterial-based therapies have emerged as a promising approach for ulcerative colitis (UC). To systematically map the field, we performed a bibliometric analysis of research over the past 25 years, aiming to reveal knowledge evolution, core themes, and emerging trends. Methods: We searched the Web of Science Core Collection and Scopus for English-language publications (2001-2025) using the keywords "nanomaterials" and "ulcerative colitis" including original articles and reviews. After deduplication, 1,316 publications were analyzed using CiteSpace, HistCite, and R to construct collaboration networks, keyword co-occurrence maps, co-citation networks, and thematic evolution analyses. Results: UC-focused nanotherapeutics show sustained growth and increasing international collaboration, with China as the leading contributor. Analysis identified 57 subject categories, 537 keywords, and 899 publications with citation bursts. Five emerging themes were highlighted: gut microbiota, reactive oxygen species, NLRP3 inflammasome, drug delivery systems, and polymeric nanoparticles. Nanotechnology is increasingly integrated into UC pathogenesis studies, with a shift from passive drug delivery toward intelligent, mechanism-driven, and combination therapies. Co-citation analysis identified seven core areas, including inflammation regulation, targeted delivery, immune modulation, hydrogel carriers, and nanotherapeutics. Conclusion: This study maps the evolving landscape of UC nanotherapeutics, highlighting the field's shift toward precise, intelligent, and mechanism-guided strategies. Future research should emphasize nanodesign, safety evaluation, and personalized therapies, facilitating translational innovation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.