Evidence map›Paper›PMID 41789075›Full record

ArticleFrontiers in immunology2026

Glycoengineering CAR-T cells to overcome galectin-3-mediated immunosuppression.

Lee Seng Lau, Maria Suarez, Brandon Fernandez, Joseph Souchak, Aristotelis Antonopoulos, Nan Hu, Maria M Abreu, Guenther Koehne, Anne Dell, Stuart M Haslam and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lee Seng LauDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.
Maria SuarezDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.
Brandon FernandezDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.
Joseph SouchakDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.
Aristotelis AntonopoulosDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Nan HuDepartment of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, United States.
Maria M AbreuMiami Cancer Institute, Baptist Health-South Florida, Miami, FL, United States.
Guenther KoehneMiami Cancer Institute, Baptist Health-South Florida, Miami, FL, United States.
Anne DellDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Stuart M HaslamDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Avery D PoseyDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Charles J DimitroffDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.

Funding

Analysis of galectin-8 and its ligands in melanoma progressionR01CA282520 · NCI · FLORIDA INTERNATIONAL UNIVERSITY · PI CHARLES J DIMITROFF · 2024 to 2026
$1.6M
NCI NIH HHS R01 CA282520
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR)-T cell therapy has transformed treatment for relapsed or refractory B-cell malignancies; however, limited

Indexed as

Galectin 3Immune ToleranceImmunotherapy, AdoptiveReceptors, Chimeric AntigenT-LymphocytesAnimalsAntigens, CDbeta-D-Galactoside alpha 2-6-SialyltransferaseCell Line, TumorHumansMiceSialyltransferasesTumor MicroenvironmentAntigens, CDbeta-D-Galactoside alpha 2-6-SialyltransferaseGalectin 3Receptors, Chimeric AntigenSialyltransferasesST6GAL1 protein, humancancer glycobiologycancer immunotherapyCAR-T cellsgalectinssialylation modification

Identifiers

PMID41789075
PMCPMC12956802

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.