ArticleFrontiers in immunology2026
Identification of immune-mediated aging genes associated with cervical spondylosis through single-cell eQTL Mendelian randomization.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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2 authors.
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Abstract
Background: Cervical spondylosis (CS) is an age-related degenerative spinal disorder with increasing evidence linking its pathogenesis to immune aging. The genetic mechanisms connecting immune dysregulation to CS remain largely undefined. Methods: We integrated GWAS data from 484,598 individuals with single-cell eQTL profiles across 14 immune cell types, using Mendelian randomization (MR) and Bayesian colocalization to identify genes whose cell-type-specific expression causally influences CS risk. Entropy analysis quantified lineage specificity of MR effects. Functional enrichment, drug-gene interaction mapping, and protein-protein interaction (PPI) network construction were used for target prioritization. Validation was performed using qPCR and ELISA in CS patient serum and 5-Aminosalicylic Acid (5-ASA) treatment in HUT78 T cells. Results: A total of 118 genes exhibited suggestive or potential causal associations with CS, primarily enriched in CD4 Conclusion: This study reveals immune cell-specific genetic regulators linking immune aging to cervical spondylosis and identifies 5-ASA as a candidate therapeutic agent. Our single-cell MR framework offers novel insights into immunogenetic mechanisms driving age-related spinal degeneration and highlights actionable targets for translational research.
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