Evidence map›Paper›PMID 41789062›Full record

ArticleFrontiers in immunology2026

Zhiyu Lu, Yizhou Lu, Di Liu, Fangzhi Du, Qingyun Wu, Guoyang Liao, Yanan Wu, Rui-Li Zhang, Jian Zhou, Qianqiu Wang

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiyu LuHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Yizhou LuDepartment of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Di LiuDepartment of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Fangzhi DuHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Qingyun WuHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Guoyang LiaoInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
Yanan WuInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
Rui-Li ZhangDepartment of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jian ZhouInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
Qianqiu WangHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Syphilis is a sexually or vertically transmitted disease caused by the infection of Methods: In this study, we successfully constructed a TP0954 mRNA vaccine and confirmed the immunogenicity of the mRNA vaccine in BALB/c mice and New Zealand White (NZW) rabbits. Then the protective immunity was assessed in immunized NZW rabbits. Results: Our mRNA vaccine elicited humoral and cellular immunological responses both in BALB/c mice and NZW rabbits. Moreover, TP0954 mRNA vaccine was more effective in attenuating lesion development compared with TP0954 protein vaccine. Similarly, the Conclusion: Therefore, we successfully constructed a novel mRNA vaccine targeting TP0954 for syphilis and found superior immune protective effects compared with TP0954 recombinant protein vaccine, further confirming that TP0954 is a promising vaccine candidate for syphilis.

Indexed as

Antigens, BacterialBacterial ProteinsBacterial VaccinesRNA, MessengerSyphilisTreponema pallidumAnimalsAntibodies, BacterialFemaleImmunity, CellularMiceMice, Inbred BALB CRabbitsAntibodies, BacterialAntigens, BacterialBacterial ProteinsBacterial VaccinesRNA, MessengerimmunoprotecionmRNA vaccinesyphilisTp0954Treponema pallidum

Identifiers

PMID41789062
PMCPMC12957224

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.