ArticleClinical, cosmetic and investigational dermatology2026
Ultra-High-Frequency Ultrasound of Melanoma Excision Scars for Detection of Clinically Occult Local Recurrence: A Single-Center Retrospective Study.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Multimodal Non-Invasive Skin Imaging in Dermatology: Current Modalities, Clinical Applications, and Future Integration.Diagnostics (Basel, Switzerland) · 2026Review
- Resolution versus Reliability: Interpreting Ultra-High-Frequency Ultrasound in Melanoma Recurrence Detection [Letter].Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High- and ultra-high-frequency ultrasound (HFUS/UHFUS) may enhance early detection of clinically occult local recurrence at melanoma excision scars, where postoperative fibrotic or inflammatory changes can obscure subtle dermal-subcutaneous foci. Methods: This single-center retrospective observational study included all consecutive patients with histologically confirmed cutaneous melanoma who underwent HFUS/UHFUS assessment of the excision scar between November 2024 and October 2025 at a tertiary referral center. Examinations were performed with a Vevo 3100 system using a 48-70 MHz linear transducer by an experienced radiologist (>10 years), following a standardized institutional protocol. Scars were classified as benign remodeling, indeterminate, or suspicious/highly suspicious according to predefined morphologic and vascular features. Suspicious/highly suspicious findings were referred for biopsy/excision; indeterminate findings underwent short-interval follow-up; benign-appearing scars were monitored per protocol. Histopathology and/or longitudinal follow-up served as reference standards. Results: Among 320 patients (730 examinations), 53 scars were categorized as suspicious/highly suspicious; recurrence was histologically confirmed in 50 cases, while 3 represented fibroblast-rich extracellular matrix remodeling. All recurrences were clinically occult at imaging. No false negatives were observed within the available follow-up of ultrasound-negative scars (median 12 months; range 3-12). Sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were 100%, 98.9%, 94.3%, 100%, and 99.1%, respectively. Conclusion: In an expert setting, HFUS/UHFUS provides highly reliable detection of subclinical local recurrence at melanoma excision sites and robust discrimination from benign postoperative changes, supporting its integration as an adjunct tool in specialized follow-up pathways.
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