ArticleFrontiers in oncology2026
Nodal status dictates divergent prognostic drivers in oral squamous cell carcinoma: metabolic burden in pN0 vs. sarcopenia and nodal burden in pN.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Oral squamous cell carcinoma (OSCC) exhibits heterogeneous outcomes based on nodal status, complicating personalized prognosis. This study aimed to identify nodal-specific prognostic factors in OSCC by integrating metabolic metrics from Methods: We conducted a retrospective cohort study of 147 OSCC patients (74 pN0, 73 pN+) who underwent curative resection and neck dissection. Associations between metabolic metrics, L3-SMI, pathological factors, and overall (OS) or progression-free survival (PFS) were evaluated using Cox regression. Internal bootstrap validation (1000 repetitions) was performed to assess the stability and potential bias of the prognostic factors. Results: In pN0 patients, tumor maximum standardized uptake value (T-SUVmax) >13.27 emerged as an independent predictor of poor OS (HR = 10.24, Conclusions: We propose a nodal status-stratified approach for risk assessment in OSCC. For pN0 necks, high risk is characterized by elevated T-SUVmax, whereas in pN+ necks, high nodal burden and sarcopenia define increased risk.
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