ArticleFrontiers in physiology2026
Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cerebrospinal fluid (CSF) pulsations are linked to hemodynamics, with autonomic mechanisms, suggested to modulate slow-wave induced pulsations. Method: To explore autonomic regulation's role in neurofluid flow, independent of sleep and neural activity, we hypothesized that modulating basal CO Results: Using resting-state BOLD fMRI in neurofluid regions under different CO Discussion: These results suggest that both hyper- and hypocapnia disrupt how CSF responds to autonomic regulation, seen in deviations from normal cardiac and respiratory responses. Our work reveals neurofluid dynamics' sensitivity to CO
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