Evidence map›Paper›PMID 41788875›Full record

ArticleFrontiers in physiology2026

Physiological and molecular dynamic changes during 23-day high-altitude exposure reveal novel biomarkers for acclimatization.

Ling Chen, Xuefei He, Hao Wang, Sihu Hu, Haitong Zhao, Guohua Ni, Hui Yan, Lei Chen, Cheng Deng, Fengming Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ling Chen *Department of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xuefei He *Department of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Hao Wang *Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sihu HuLaboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Haitong ZhaoDepartment of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Guohua NiDepartment of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Hui YanEmergency Management Office, West China Hospital, Sichuan University, Chengdu, China.
Lei ChenDepartment of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Cheng DengDepartment of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Fengming LuoDepartment of High Altitude Medicine, High Altitude Medicine Key Laboratory of Sichuan Province, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Health conditions associated with rapid ascent to high altitudes remain prevalent and pose an ongoing challenge. While acute mountain sickness (AMS) typically occurs within the first few days after ascent, the physiological and molecular acclimatization processes during prolonged high-altitude exposure beyond the initial acute phase remain incompletely understood. Methods: This cross-sectional study investigated physiological and transcriptomic dynamics during prolonged high-altitude exposure over a 23 day period at 4,104 m in 113 Chinese Han individuals. Linear regression analysis, time series analysis, enrichment analysis, and protein-protein interaction analysis were applied to reveal the physiological and molecular dynamic changes. Results: Four physiological parameters (saturation of peripheral oxygen [SpO Conclusion: This study provides critical insights into key physiological trends and molecular expression dynamics associated with prolonged exposure to high-altitude environments.

Indexed as

acclimatization processacute mountain sickness (AMS)gene expression pattern (GEP)high-altitude exposuretemporal transcriptome analysis

Identifiers

PMID41788875
PMCPMC12956708

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