ArticleFrontiers in pharmacology2026
Quercetin attenuates acute alcohol-induced liver injury in mice by modulating lipid metabolism, oxidative stress, and inflammation.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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4 authors.
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Abstract
Background: Alcoholic liver disease (ALD) remains a major global health burden, and effective therapeutic options are limited. Quercetin, a dietary flavonoid with antioxidant and anti-inflammatory properties, has shown hepatoprotective potential, but its mechanisms in acute alcohol-induced liver injury require clarification. Methods: Fifty male BALB/c mice were randomly divided into five groups (n = 10/group): control (CG), model (MG), low-dose quercetin (LQ, 50 mg/kg), high-dose quercetin (HQ, 100 mg/kg), and oyster soybean carnitine mice in the oyster soybean carnitine group (OG) were administered oyster soybean carnitine at a volume of 20 mL/kg.(OG, 20 mL/kg). All treatments were administered orally once daily for 14 days. Acute alcohol injury was induced on Day 14 using 52% (v/v) ethanol. Behavioral intoxication indices, serum biochemistry, liver oxidative stress markers, inflammatory cytokines, histopathology, lipid accumulation, and the expression of lipid-metabolismrelated genes and proteins (FAS, SCD1, ACC1, CPT1, PGC-1α, PPARα) were assessed. Results: HQ significantly prolonged alcohol tolerance time (P < 0.01) and shortened sober-up time (P < 0.01). HQ markedly reduced serum AST, ALT, TG, FFA, and glycerol levels (P < 0.01). Quercetin also lowered hepatic TG, TNF-α, and IL-6 and increased SOD, GSH, and CAT activities. Histological and Oil Red O staining confirmed reduced steatosis. Mechanistically, quercetin downregulated hepatic FAS, SCD1, and ACC1 while upregulating CPT1, PGC-1α, and PPARα at both mRNA and protein levels. Conclusion: Quercetin exerts hepatoprotective effects against acute alcohol-induced liver injury through coordinated regulation of lipid metabolism, oxidative stress, and inflammatory responses.The study did not include a quercetin-only group or measure blood ethanol levels, which should be addressed in future work.These findings support the potential of quercetin as a natural candidate for preventing alcohol-related hepatic injury.
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