SynthesisFrontiers in endocrinology2026
Association between neutrophil to lymphocyte ratio and the risk of vertebral fracture in patients with osteoporosis: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of prognostic nutritional index with fecal incontinence and fecal incontinence severity index in individuals with osteoporosis: mediating roles of C-reactive protein and gamma-glutamyl transferase.Frontiers in nutrition · 2026Article
- Development and validation of a robust logistic regression model for predicting osteoporosis in older people.Frontiers in medicine · 2026Article
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2 authors.
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Abstract
Background: Vertebral fractures, which account for 40% of osteoporotic fractures, often lack early clinical symptoms. Previous studies have shown that neutrophil-to-lymphocyte ratio (NLR) has potential predictive value for vertebral fractures, but evidence-based conclusions are lacking. This meta-analysis is the latest to evaluate the link between NLR and vertebral fracture risk in patients with osteoporosis. Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane, Wanfang and CNKI (up to March 2025). The search was performed using the following keywords: "Neutrophils", "Lymphocytes", "Osteoporosis", and "Fracture". Odds ratio (OR) and standardized mean difference (SMD) with 95% confidence intervals (CIs) were used for the data synthesis of categorical and continuous variables, respectively. Sensitivity analysis was performed to explore the stability of the results and possible sources of heterogeneity. All analyses were performed using Review Manger 5.4 and STATA 15.0. Results: Six observational studies (n=938) were included. Categorical data showed a significantly higher vertebral fracture risk in high-NLR groups (OR = 3.75, 95% CI:1.79-7.86; Conclusion: Higher NLR values in osteoporotic patients are significantly associated with an increased risk of vertebral fractures, but the strength of this evidence is limited by high heterogeneity and the instability of results from continuous variables. Current findings support NLR as a potential inflammation-related biomarker for vertebral fractures, but its clinical application requires careful interpretation. Future research should focus on conducting more high-quality, large-sample prospective studies to standardize NLR thresholds and validate its practical value in risk stratification for osteoporotic fractures. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/, identifier CRD420251023391.
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