ArticleFrontiers in medicine2026
A modified partition of peripapillary atrophy in high myopia based on optical coherence tomography.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study investigates morphological changes in peripapillary atrophy (PPA) in high myopia (HM) patients, aiming to refine PPA zoning characteristics to enhance clinical diagnosis and treatment of HM. Design: This study is categorized as a retrospective cross-sectional model. Methods: We retrospectively reviewed 172 patients (316 eyes) with comprehensive medical records, categorizing them into a pathological myopia (PM) cohort-subdivided into PM1 (≥30 mm), PM2 (≥28 and <30 mm), PM3 (<28 mm)-and a simple HM group, based on fundus pathology and axial length (AL). We collected data on spherical equivalent (SE), best corrected visual acuity (BCVA), intraocular pressure (IOP), AL, and posterior optical coherence tomography (OCT). For posterior OCT, we manually measured improved landmark features based on the original PPA zoning: Scleral Curvature Angle (SCA), Scleral Flange Curvature Angle (SFCA), PPA1-4 zone, scleral flange length (SFL), and mean scleral flange thickness (MSFT). The Bland-Altman method assessed measurement consistency, and statistical comparisons were made of the modified PPA feature parameters across the groups. Results: An increase in AL and progression from simple HM to PM were associated with increases in age, AL, and IOP, along with decreases in BCVA and SE across all groups. The parameters SCA, SFCA, and PPA1-4 zones showed a general increase, whereas MSFT differences were not statistically significant ( Conclusion: The modified PPA partition based on OCT imaging identifies 6 key zoning features: PPA1-4, SCA, and SFCA. These are correlated with longer AL and advanced fundus changes in HM patients. In particular, PPA1 and SCA emerge as vital indicators for assessing HM conditions using OCT imaging.
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