ArticleFrontiers in medicine2026
Triple-negative ovarian apocrine carcinoma arising in a giant mature cystic teratoma: Case Report and Case Review.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Mature cystic teratoma (MCT) of the ovary is one of the most common benign ovarian neoplasms in women of reproductive age. Malignant transformation is rare, occurring in approximately 1-2% of cases, and transformation into apocrine carcinoma is exceptionally uncommon. To date, only four such cases have been reported. Case presentation: We describe a 68-year-old woman with a giant ovarian tumor that had been slowly growing for over 40 years. Imaging revealed a 35 cm cystic mass, consistent with malignant degeneration and serum CA-125 was elevated (559 U/mL). The patient underwent exploratory laparotomy with complete removal of a 11 kg right ovarian tumor. Histopathological examination revealed a mature cystic teratoma of the ovary with malignant transformation into high-grade apocrine carcinoma. The tumor involved the cyst wall multifocally and showed no capsular rupture. Immunohistochemistry showed AR and EGFR positivity, ER and PR negativity, and HER2 score 2+ (FISH negative). The PET-CT showed 2 pericaval lymph nodes possible reactive after surgery. The postoperative course was uneventful, and from the outset the patient refused a comprehensive staging with hysterectomy, omentectomy and lymphadenectomy. At 6-month follow-up, CA-125 remained normal (<8 U/mL), with no evidence of recurrence. Conclusion: Ovarian apocrine carcinoma arising in MCT is exceedingly rare. Complete surgical excision remains the cornerstone of treatment, as no standard systemic therapy has been established. Further accumulation of similar cases is essential to better understand the biological behavior and optimize management of this rare tumor type.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.