Evidence map›Paper›PMID 41788695›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2026

Ocular Surface Microbiota Alterations Following FS-LASIK and Their Association With Postoperative Dry Eye.

Jingjing Xu, Chiwen Cheng, Kang Yu, Qing Wang, Yangyang Peng, Yanqing Li, Wen Yao, Yijie Pi, Shuhuan Yu, Zerui Han and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06448468 (Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06448468 unknown statusnot on this map

Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis (FS-LASIK)

TypeobservationalSponsorSecond Affiliated Hospital of Nanchang UniversityRan2024 to 2024Enrolled200ConditionsRefractive Surgery
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Ocular Surface Microbiota Alterations Following FS-LASIK and Their Association With Postoperative Dry Eye.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jingjing XuOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Chiwen ChengOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Kang YuOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Qing WangOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Yangyang PengOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Yanqing LiOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Wen YaoOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Yijie PiOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Shuhuan YuSchool of General Practice, Gannan Medical University, Ganzhou, Jiangxi, China, gmu.cn.
Zerui HanJiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Jing WeiNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.
Tingtao ChenNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.ORCID https://orcid.org/0000-0002-0506-8536
Yifeng YuOphthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, ncu.edu.cn.ORCID https://orcid.org/0000-0002-6598-2274

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Given the limited evidence on ocular surface microbiota (OSM) changes after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and their link to dry eye (DE), this study aimed to compare microbial profiles in patients with and without postoperative DE, offering a basis for early detection and targeted treatment. Methods: Patients undergoing FS-LASIK were evaluated 3 months postoperatively and stratified into DE ( Results: Comparative analysis of the OSM revealed significantly higher α-diversity in the DE group compared to the NDE group. At the phylum level, a decrease in Proteobacteria and an increase in Bacteroidetes were observed. At the genus level, Conclusions: In summary, dysbiosis between the Trial Registration: ClinicalTrials.gov identifier: NCT06448468.

Indexed as

16S rRNAdry eyeFS-LASIKocular surface microbiome

Identifiers

PMID41788695
PMCPMC12957956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.