Evidence map›Paper›PMID 41788677›Full record

ArticleFrontiers in nutrition2026

Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study.

Doudou Zhao, Yanfang Song, Liang Li, Nan Li, Yu Zhang, Yiting Li, Kangxin Wang, Yang Mi, Lei Shang, Pengfei Qu

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Doudou ZhaoTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, China.
Yanfang SongDepartment of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
Liang LiDepartment of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
Nan LiDepartment of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
Yu ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yiting LiDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Kangxin WangDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Yang MiDepartment of Obstetrics, Northwest Women's and Children's Hospital, Xi'an, China.
Lei ShangDepartment of Health Statistics, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, China.
Pengfei QuTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Neonatal growth holds great significance for lifelong health, but the effects of maternal mineral nutrition during pregnancy on neonatal growth remain unclear. This study aimed to investigate the associations of the maternal mineral nutrition including copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg), and iron (Fe) during early pregnancy with neonatal growth. Methods: A prospective cohort study was conducted in Xi'an, China, with a total of 5,629 mother-infant dyads. The study examined the non-linear relationship and threshold effects between minerals and neonatal growth using smoothed plots and two-piecewise regression models. Results: Every one-unit elevation in log-transformed Ca concentration was associated with a 97% (RR: 0.03, 95% CI: 0.01-0.80) lower risk of small-for-gestational-age (SGA). Maternal Fe concentration was associated with birth length of male infants in an inverted U-shaped curve. When Fe concentration was less than 7.24 mmol/L, a one-unit elevation in log-transformed Fe concentration was associated with a 3.23-cm higher birth length (95% CI: 0.13-6.32) in male infants. However, this relationship was not found in female infants. Conclusion: Adequate maternal Ca and Fe in early pregnancy may benefit newborn growth and development, but the gender differences should also be considered. Vigilant monitoring and prompt remediation of maternal mineral deficiencies during early pregnancy are essential for optimizing neonatal health outcomes.

Indexed as

birth lengthcalciumcohort studyironmaternal mineral nutritionnon-linear relationshipSGA

Identifiers

PMID41788677
PMCPMC12956538

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