ReviewJournal of ginseng research2026
Research progress of ginseng active ingredients combined with chemotherapy in cancer therapy.
Review in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Insights into Enzymes Involved in the Biosynthesis of Protopanaxadiol-Type Ginsenosides inACS omega · 2026Review
- Epigenetic activation of NK-cell effector programs and caspase-8-dependent apoptosis mediates the antitumor activity of LGP in NSCLC.Journal of ginseng research · 2026Article
- Bioactive Constituents of Ginseng in Cancer Therapy: Molecular Mechanisms, Translational Potential, and Advanced Delivery Strategies.International journal of biological sciences · 2026Review
- Protective effect ofFrontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotherapy remains a cornerstone of cancer therapy and is widely employed in clinical practice. However, the therapeutic effect of chemotherapy is often hindered by drug resistance and adverse effects. Recent studies have highlighted the potential of ginseng active ingredients in combination with chemotherapy. This review systematically summarizes that ginseng active ingredients can not only inhibit tumor proliferation by promoting cancer cell apoptosis and arresting cancer cell cycle, inhibit tumor metastasis by suppressing epithelial-mesenchymal transition (EMT) and angiogenesis at the tumor site, but also reverse drug resistance by suppressing intracellular drug efflux and tumor immune evasion, and at the same time they can alleviate organ toxicities including nephrotoxicity, hepatotoxicity, cardiotoxicity, gastrointestinal toxicity, and ototoxicity as well as toxicities to the nervous system, hematopoietic system, and immune system induced by chemotherapy through multiple mechanisms, which shows great promise in cancer therapy. It elaborates the pharmacological actions of key constituents including ginsenoside Rg3 and Rh2, while incorporating innovative research findings on constituents including pseudoginsenoside F11, ginseng polysaccharides, and lipids. Furthermore, this review also specifically focuses on cutting-edge mechanisms including ferroptosis and pyroptosis, which enriches the theoretical basis of the application of ginseng active ingredients in cancer therapy and provides novel research directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.