Evidence map›Paper›PMID 41788572›Full record

ArticleJournal of ginseng research2026

A novel black ginseng processing method for optimizing rare ginsenosides with bioactivity and sustainability.

Jeong Hun Cho, Seungjo Lee, Joon Soo Chun, Chan-Su Rha, Sehyun Kim, Hyung-Min Kim, Donghyun Kim, Min-Seuk Lee, Hyoung-June Kim, Eun Jin Lee

Abstract read
In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeong Hun ChoResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Seungjo LeeOsulloc Tea R&D Center, Osulloc Farm Corporation, Seogwipo, 63521, Republic of Korea.
Joon Soo ChunResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Chan-Su RhaResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Sehyun KimResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Hyung-Min KimResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Donghyun KimResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Min-Seuk LeeOsulloc Tea R&D Center, Osulloc Farm Corporation, Seogwipo, 63521, Republic of Korea.
Hyoung-June KimResearch and Innovation Center, AMOREPACIFIC, Yongin, 17071, Republic of Korea.
Eun Jin LeeDepartment of Agriculture, Forestry and Bioresources, College of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional black ginseng (BG) production requires resource-intensive multiple steaming-drying cycles. This study aimed to develop an efficient, sustainable method for producing novel black ginseng (hereafter referred to as Dark Ginseng, DG) with optimized rare ginsenoside contents with biological efficacy. Methods: A sous vide-inspired enclosed system heating method was used, where sealed packaging retained water vapor to enable continuous moisture-mediated ginsenoside hydrolysis, fundamentally different from conventional open-system steam processing. Response surface methodology was employed to optimize the production parameters. DG underwent comprehensive morphological, colorimetric, and phytochemical characterizations. Biological activities were assessed by quantifying collagen gene expression in fibroblasts and inflammatory marker levels in keratinocytes. Results: Optimal parameters (3-fold water ratio, 100 °C, 120 h duration) demonstrated excellent agreement with the regression model. DG exhibited physical features comparable to conventional BG, while achieving reduced processing time (42 %), lower carbon dioxide emissions (64 %), and cost reduction (81 %), and contained rare ginsenosides (ginsenosides Rg Conclusions: This innovative process developed in this study replaces the nine sequential steaming-drying cycles required for conventional BG production, with a single sequence involving sous vide-like heating, offering sustainability and economic advantages, while suggesting potential for applications in cosmetics and functional foods.

Indexed as

Anti-inflammationGinsengRare ginsenosidesResponse surface methodologySkin elasticitySustainable ginseng processing

Identifiers

PMID41788572
PMCPMC12959307

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.