Evidence map›Paper›PMID 41788507›Full record

ArticleEuropean heart journal open2026

Association between depression and risk of ischaemic stroke in patients with atrial fibrillation.

Keitaro Senoo, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Toshiyuki Ko, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Norihiko Takeda and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keitaro SenooDepartment of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID https://orcid.org/0000-0002-8597-7165
Hidehiro KanekoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0003-2553-6170
Yuta SuzukiDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Akira OkadaDepartment of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-6480-3388
Toshiyuki KoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-9043-064X
Katsuhito FujiuDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-1889-9291
Norifumi TakedaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0003-4818-3347
Hiroyuki MoritaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Koichi NodeDepartment of Cardiovascular Medicine, Saga University, Saga 849-8501, Japan.ORCID https://orcid.org/0000-0002-2534-0939
Norihiko TakedaDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Hideo YasunagaDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan.
Satoaki MatobaDepartment of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Atrial fibrillation (AF) is a major cause of ischaemic stroke (IS), and its risk is assessed using existing risk stratification scores. However, the impact of psychiatric comorbidities such as depression on this risk has not been sufficiently considered. Depression is commonly observed in individuals with AF and is increasingly recognized as an independent risk factor for IS. This study aimed to examine the association between depression and the risk of IS in AF. Methods and results: A cohort study of individuals with AF was conducted using a large Japanese healthcare database. Hazard ratios (HR) for IS in patients with depression were estimated using a multivariable Cox proportional hazards model, adjusting for established cardiovascular risk factors and medication use (e.g. anticoagulant therapy). Additional analyses included age- and sex-stratified analyses, time-dependent models, and sensitivity analyses to assess reverse causality bias. A total of 22 939 individuals with AF were included in the analysis. Among them, 1774 patients (7.7%) had a diagnosis of depression at baseline. During follow-up, IS occurred at a higher rate in individuals with depression. Multivariate analysis demonstrated that depression was an independent and significant predictor for IS (HR 1.39, 95% confidence interval 1.16-1.66, Conclusion: This study demonstrates that depression in individuals with AF is a predictor of IS, independent of established cardiovascular risk factors. These findings highlight the potential importance of screening for depression as part of the holistic risk assessment for patients with AF.

Indexed as

Atrial fibrillationCohort studyDepressionRisk factorStroke

Identifiers

PMID41788507
PMCPMC12958021

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.