ArticleEuropean heart journal open2026
Right ventricular global constructive work as an echocardiographic predictor of worsening heart failure.
Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Right Ventricular Myocardial Work by Echocardiography: A Scoping Review of Methodology, Validation, and Clinical Applications.Echocardiography (Mount Kisco, N.Y.) · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Worsening heart failure (WHF) is a pivotal event in the trajectory of chronic heart failure, yet early risk stratification remains challenging. Echocardiographic right ventricular myocardial work (RVMW), a pressure-strain-integrated index, may offer incremental prognostic value beyond conventional echocardiographic and biomarker-based markers. This study assessed whether right ventricular global constructive work (RVGCW), the principal component of RVMW, predicts WHF and cardiovascular mortality. Methods and results: In this prospective study, we enrolled 215 ambulatory patients with chronic heart failure New York Heart Association Functional Class (II-IV), encompassing heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction, all in sinus rhythm and receiving guideline-directed medical therapy. Comprehensive transthoracic echocardiography was performed using a GE Vivid E95 system with offline analysis (EchoPAC v204). Right ventricular myocardial work was quantified using a non-invasive pressure-strain loop methodology, and RVGCW was prespecified as the primary RVMW parameter of interest. Right ventricular global constructive work was derived from right ventricular pressure-strain loops integrating right ventricular (RV) global strain and estimated pulmonary pressures. Patients were followed for 24 months with scheduled 3-month assessments and additional visits for suspected WHF. The primary endpoint was composite WHF, defined as heart failure hospitalization or adjudicated subclinical WHF.Baseline RVGCW was significantly lower in patients who developed WHF compared with those who did not (607 ± 48 vs. 648 ± 52 mmHg%, Conclusion: Echocardiographic RVGCW is a strong, independent predictor of WHF and provides substantial incremental prognostic information beyond traditional markers; its association with cardiovascular mortality was exploratory.
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