Evidence map›Paper›PMID 41788481›Full record

ArticleAnnals of intensive care2026

Efficiency of neural respiratory drive changes during non-invasive ventilation and high-flow nasal cannula oxygen therapy in AECOPD patients with acute hypercapnic respiratory failure: A randomised cross-over study.

Lili Guan, Jiawen Xu, Zhenfeng He, Shanshan Zha, Qiaoyun Huang, Jianyi Niu, Luqian Zhou, Rongchang Chen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04212182 (The Physiological Effect of High Flow Oxygen Therapy on Acute Exacerbation of Chronic Obstructive Pulmonary Disease), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04212182 naunknown statusnot on this map

The Physiological Effect of High Flow Oxygen Therapy on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorThe First Affiliated Hospital of Guangzhou Medical UniversityRan2019 to 2020Enrolled10ConditionsHigh-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation, Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseArmsHFNC, NPPV
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lili GuanGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Jiawen XuGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Zhenfeng HeGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Shanshan ZhaGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Qiaoyun HuangGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Jianyi NiuGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Luqian ZhouGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.
Rongchang ChenGuangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-invasive ventilation (NIV) is recommended as the first-line treatment for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by decompensated hypercapnic acute respiratory failure (ARF). High-flow nasal cannula oxygen therapy (HFNO), given its superior tolerance and patient adherence, has emerged as a promising alternative non-invasive respiratory support modality applicable across a wider range of clinical scenarios. This study aimed to investigate the neurophysiological effects of NIV and HFNO in AECOPD patients with hypercapnic ARF. Methods: A prospective, randomised, crossover trial involving 10 AECOPD patients with decompensated hypercapnic ARF was conducted. Each patient underwent 30 min of treatment with both NIV and HFNO, with the neural respiratory drive (NRD) measured via a multi-pair oesophageal electrode catheter. Results: NIV significantly improved neuro-ventilatory coupling compared with HFNO (treatment difference: 1.73 L/%, 95% CI: 0.95 to 2.51 L/%, Conclusion: In AECOPD patients with decompensated hypercapnic ARF, NIV significantly enhances NRD efficiency and reduces respiratory workload and related respiratory mechanics. HFNO, while less effective than NIV, still confers measurable physiological benefits and may serve as a viable alternative in resource-limited settings or those who are intolerant to NIV, potentially more appropriate for patients with less severe respiratory failure. Trial registration: ClinicalTrials.gov, NCT04212182. Registered 23 December 2019, https://clinicaltrials.gov/study/NCT04212182.

Indexed as

High-flow nasal cannula oxygen therapyNeural respiratory driveNon-invasive ventilation

Identifiers

PMID41788481
PMCPMC12934410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.