Evidence map›Paper›PMID 41788204›Full record

ArticleMiddle East journal of digestive diseases2025

Evaluating the Correlation Between Fecal Microbiota Profiles and Clinical Presentation in Pediatric Patients with Celiac Disease.

Nastaran Asri, Mohadeseh Mahmoudi Ghehsareh, Fahimeh Sadat Gholam-Mostafaei, Mehdi Azizmohammad Looha, Hamidreza Houri, Somayeh Jahani-Sherafat, Mohammad Rahmanian, Mostafa Rezaei Tavirani, Mohammad Rostami-Nejad

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Article in Middle East journal of digestive diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nastaran AsriStudent Research Committee, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-1986-615X
Mohadeseh Mahmoudi GhehsarehCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fahimeh Sadat Gholam-MostafaeiCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi Azizmohammad LoohaBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamidreza HouriFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh Jahani-SherafatLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad RahmanianCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mostafa Rezaei TaviraniProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Rostami-NejadCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-2495-1831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Celiac disease (CD) is an immune-mediated disorder triggered by gluten in genetically susceptible individuals, often presenting with diverse gastrointestinal and non-gastrointestinal symptoms. Emerging evidence suggests that alterations in gut microbiota composition may influence disease manifestation and clinical outcomes. We investigated the correlation between gut microbiota profiles and clinical features in pediatric patients with CD. Methods: 38 pediatric patients (mean age 10.24 years) with confirmed CD were enrolled from August 2021 to September 2022. We had the data on the relative abundance of various fecal microbiota from our previous study, and collected their clinical and demographic data through questionnaires. Genotyping of human leukocyte antigens (HLA)-DQ2 and HLA-DQ8 alleles was performed. Results: Significant correlations were found between gut microbiota and both gastrointestinal (GI) and non-GI symptoms. Enterobacteriaceae and Conclusion: Overall, the analysis revealed distinct microbiota patterns influenced by symptom presentation and HLA-DQ genotypes, underscoring the need for further research into the therapeutic potential of modifying gut microbiota in managing CD.

Indexed as

Celiac diseaseGastrointestinal symptomsGut microbiotaHLA-DQ genotypePediatric patients

Identifiers

PMID41788204
PMCPMC12958314

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