Evidence map›Paper›PMID 41788197›Full record

ReviewFrontiers in cellular neuroscience2026

Advances in multiscale myelin imaging: from classical histology to functional insights.

Kentaro Okuyama, Yuji Komaki, Motonari Ishihara, Yuma Kurosaki, Saki Tsuchiya, Manabu Hayatsu, Junpei Nakayama, Keiko Uchiyama, Kosuke Itoh, Toshihiro Nagai and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kentaro Okuyama *Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yuji KomakiBioimaging Center, Central Institute for Experimental Medicine and Life Science, Kanagawa, Japan.
Motonari Ishihara *Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yuma Kurosaki *Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Saki Tsuchiya *Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Manabu HayatsuDivision of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Junpei NakayamaDivision of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Keiko UchiyamaDivision of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Kosuke ItohCenter for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata, Japan.
Toshihiro NagaiElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Tomoko ShindoElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Nobuko MoritokiElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, Japan.
Hiroyuki KawashimaDivision of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Shinsuke ShibataDivision of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientific understanding of myelin, the lipid-rich sheath of axons essential for vertebrate rapid neuronal communication, has evolved considerably. Enabled by major advances in imaging technology, research has shifted from viewing myelin as a static insulator to investigating the dynamic roles of myelinating glia in nervous system development, function, and pathophysiology. This review aimed to provide a comprehensive, multi-scale overview of the imaging toolkit for myelin biology, from foundational histology to cutting-edge advances. At the macro- and meso-scales, non-invasive modalities like magnetic resonance imaging and positron emission tomography reveal

Indexed as

electron microscopyimaginglight microscopymyelinnon-invasive imagingoligodendrocytesschwann cells

Identifiers

PMID41788197
PMCPMC12956672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.