ArticleFrontiers in cardiovascular medicine2025
Comparison of 3C4L and 2C3L radiofrequency ablation strategies for persistent atrial fibrillation: procedural profile and 2-year outcomes.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the effects of 3C4L vs. 2C3L radiofrequency ablation strategies on quantitative myocardial motion parameters and serum biomarkers in patients with persistent atrial fibrillation. Methods: A retrospective study was conducted on 105 patients with persistent atrial fibrillation who underwent radiofrequency ablation treatment at our hospital between March 2023 and November 2024. All patients' data were obtained from the medical record system. Patients were divided into two groups based on the ablation strategy employed: a 2C3L group ( Results: There was no statistically significant difference in circumferential pulmonary vein isolation ablation time, cavotricuspid isthmus ablation time, and left atrial apical line ablation time between the 3C4L group and the 2C3L group ( Conclusion: Compared with the 2C3L radiofrequency ablation strategy, the 3C4L strategy, while requiring longer procedure time, does not significantly increase complication rates and demonstrates superior clinical efficacy with better improvement in cardiac function and long-term arrhythmia-free survival. These findings should be interpreted cautiously given the retrospective, non-randomized study design and require validation through prospective randomized controlled trials.
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