ArticleJournal of traditional and complementary medicine2026
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats.
Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim: Asthenozoospermia (AZS) is a vital factor that causes male infertility. Qiangjing Tablets (QJT) is a Chinese medicine preparation that has good effects on improving kidney function and sperm motility. Although the effect of QJT on the AZS has been confirmed, its mechanism has not been completely elucidated. This study aimed to investigate the therapeutic effect of QJT on ornidazole (ORN) -induced AZS rats and its mechanism. Experimental procedure: ORN was used to establish an AZS rat's model. QJT and LY294002 (PI3K inhibitor) were supplied to the ORN-induced rats. H&E staining, ELISA, Western blot, and 16S rRNA sequencing were performed. Results: Activating transcription factor 6 (ATF6), C/EBP-homologous protein (CHOP), PKR-like endoplasmic reticulum kinase (PERK), and p-PERK levels were enhanced in the ORN-treated rats, which were increased with the LY294002 administration. The opposite results were observed in PI3K, p-PI3K, Akt, p-Akt, HO-1, and Nrf-2 levels. QJT treatment improved the pathological manifestations, oxidative stress and ER stress, and enhanced the expressions of PI3K, p-PI3K, Akt, and p-Akt. ORN induced a decrease in the Conclusions: QJT modulated oxidative stress and ER stress via the PI3K/Akt/NRF-2 signaling axis and maintained gut microbiota homeostasis in AZS rats. This study will lay a theoretical basis for the treatment of AZS and male fertility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.