Evidence map›Paper›PMID 41787994›Full record

ReviewAnti-cancer agents in medicinal chemistry2026

Fish-Derived Antimicrobial Peptides (AMPs) as Anticancer Agents: A Mini-Review of

Muhammad Akram Mohd Noordin, Ahmed Abdulkareem Najm, Herryawan Ryadi Eziwar Dyari, Douglas Law, Shazrul Fazry

Abstract readReview
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In one paragraph

Review in Anti-cancer agents in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Akram Mohd NoordinDepartment of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.
Ahmed Abdulkareem NajmDepartment of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.
Herryawan Ryadi Eziwar DyariDepartment of Earth Sciences and Environment, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.
Douglas LawFaculty of Health and Life Sciences, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia.
Shazrul FazryDepartment of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMarine fish provide a significant reservoir of Antimicrobial Peptides (AMPs) with potential anticancer properties, an area of growing scientific focus.

methodsThis review gathers findings from studies published between 2020 and 2024, sourced from databases such as Google Scholar, Scopus, BioMed Central, and ScienceDirect, identifying 15 relevant research papers highlighting the potential of fish-derived antimicrobial peptides in anticancer research.

resultsAMPs exhibit broad-spectrum anticancer activity against diverse cancer cell lines, primarily by inducing apoptosis or necrosis through mechanisms that involve ROS generation, mitochondrial dysfunction, and DNA damage. DISCUSSION: The therapeutic promise of fish AMPs is rooted in their diverse mechanisms, including highly selective cytotoxicity and the ability to exploit oxidative stress and trigger irreversible cell death, along with antiangiogenic properties. Future clinical development requires synthetic optimization and advanced drug delivery systems to enhance stability, bioavailability, and targeted delivery.

conclusionThis study highlights the promise of fish antimicrobial peptides as an additional class of anticancer therapies and explores future prospects, including improvements in drug administration and peptide modification, that might enhance their clinical application.

Indexed as

Antimicrobial PeptidesAntineoplastic AgentsFishesNeoplasmsAnimalsApoptosisCell ProliferationDrug Screening Assays, AntitumorHumansAntimicrobial PeptidesAntineoplastic Agentsanti-cancerAntimicrobial peptideapoptosisbioactive peptidechemotherapyDNA repairfish

Identifiers

PMID41787994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.