ArticleAnimal models and experimental medicine2026
Wireless blood pressure sensor implantation in sheep: A detailed technique.
Article in Animal models and experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Biomedical research and preclinical testing in large animal models are essential for developing and evaluating new medical devices. This ovine study presents a stepwise implantation protocol and initial experiences with a wireless blood pressure implant sensor, enabling continuous telemetric monitoring in sheep. Adult female Jezersko-Solčava sheep underwent implantation of a wireless blood pressure sensor into the ascending aorta via the right carotid artery. The body of the device can was positioned subcutaneously in the lower neck region. After skin closure, a computed tomography scan was performed to verify sensor tip location. If malposition was detected, surgical revision was undertaken immediately. Wireless blood pressure monitoring was conducted over a 24 h period in a custom-designed sheep barn. Twelve adult female sheep successfully underwent the implantation procedure, with no major complications reported. Sensor catheter revision was required in three animals (25%). The mean duration of the procedure (from incision to skin closure) was 36 ± 10 min. During the 24 h monitoring period, the average systolic and diastolic blood pressures were 93 ± 6 and 65 ± 5 mmHg, respectively. Large animal models, particularly sheep, are indispensable in cardiovascular device research due to their anatomical and physiological similarities to humans. This study demonstrates a rapid, minimally invasive protocol for wireless blood pressure sensor implantation in sheep, offering a valuable platform for chronic telemetric monitoring in the development of cardiovascular medical devices.
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