Evidence map›Paper›PMID 41787937›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1-Regulated Ribosome Biogenesis.

Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang and 16 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

26 authors.

Mengke LiInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Yuxin WuTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Shuai ZhouTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Peipei TangJiangsu Province Engineering Research Center of Precise Prevention in the Digestive and Reproductive System Cancers, Institute of Medicinal Biotechnology, Jiangsu College of Nursing, Huai'an, Jiangsu, China.
Jiaming WeiJiangsu Province Engineering Research Center of Precise Prevention in the Digestive and Reproductive System Cancers, Institute of Medicinal Biotechnology, Jiangsu College of Nursing, Huai'an, Jiangsu, China.
Ling LiuJiangsu Province Engineering Research Center of Precise Prevention in the Digestive and Reproductive System Cancers, Institute of Medicinal Biotechnology, Jiangsu College of Nursing, Huai'an, Jiangsu, China.
Zhenyi WangMedical Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Deyang ShiInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Shengnan YuanSchool of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Qingyu ZhangTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Shihui WangInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Qing ZhangTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Huan ZhaoTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Rui ZhangTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Yingying WangTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Shiwei YangInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Xiangli ChenInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Xiaojing ShiLaboratory Animal Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Guangzhi LiuInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Yuwei ZhangInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Jinming LiTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xu Dong ZhangTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Rick F ThorneTranslational Research Institute, Henan International Join Laboratory of Non-coding RNA and Metabolism in Cancer,Henan Provincial People's Hospital,Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Dongping WeiMedical Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zumin ZhuInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
Song ChenInstitute of Hematology, Henan Key Laboratory of Stem Cell Differentiation and Modification, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.ORCID https://orcid.org/0000-0001-6412-5740

Funding

Henan Province and Ministry of Health of Medical Science and Technology Program SBGJ202403001National Natural Science Foundation of China 32570881National Natural Science Foundation of China 81872393National Natural Science Foundation of China 82300135National Natural Science Foundation of China 82400143National Natural Science Foundation of China 82470184National Natural Science Foundation of China U2004138Science and Technology Research Project of Henan Province 242102310029Science and Technology Research Project of Henan Province 242102311148
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) sustain lifelong blood production by balancing self-renewal and differentiation. The mechanisms regulating HSC homeostasis, particularly those involving ribosome biogenesis, remain incompletely understood. Here, we identify DCAF13 as a critical regulator of HSC maintenance by stabilizing RRS1, a key factor in ribosome biogenesis. Conditional deletion of Dcaf13 in murine hematopoietic cells results in severe pancytopenia, rapid mortality, and complete HSC depletion in both fetal and adult hematopoietic compartments. We show that DCAF13 deficiency disrupts ribosome assembly and protein synthesis, selectively affecting the translation of mRNAs from genes involved in myeloid differentiation, chromatin remodeling, and erythroid homeostasis. DCAF13 directly binds RRS1 and catalyzes its K27-linked polyubiquitination, a non-degradative post-translational modification that enhances RRS1 protein stability.While Dcaf13 deletion activates the p53 pathway, Trp53 ablation only partially restores HSC numbers and cell cycle progression, and does not prevent apoptosis and hematopoietic failure, indicating the involvement of both p53-dependent and p53-independent mechanisms. These findings establish a DCAF13-RRS1 axis essential for HSC function, in which DCAF13 acts as an essential regulator of ribosome biogenesis. This work provides molecular insights into the pathogenesis of hematopoietic disorders and ribosomopathies.

Indexed as

Hematopoietic Stem CellsRibosomesAnimalsMiceDCAF13HSCP53ribosome biogenesisRRS1

Identifiers

PMID41787937
PMCPMC13170182

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