Evidence map›Paper›PMID 41787915›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy.

Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu and 2 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenqi YuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yang LiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Kang KangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Jianfeng YuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xiaowei XiaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yaoge DengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yingjie LuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Lisong LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Wu XuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yijian ZhangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xuesong ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0003-2547-1119

Funding

Basic Research Pilot Project Suzhou SSD2024062Basic Research Pilot Project Suzhou SSD2025026China Postdoctoral Science Foundation 2024M762313China Postdoctoral Science Foundation 2025T180666Key Project of Jiangsu Health Commission K2023079National Key R&D Program of China 2022YFC2502902National Nature Science Foundation of China 82272494National Nature Science Foundation of China 82402864National Nature Science Foundation of China 82472452Natural Science Foundation of Jiangsu Province BK20240368Suzhou Medical College of Soochow University-Cheeloo College of Medicine Research Foundation 24QL200201
6 · The paper itself

Abstract

Hyperthermia is a well-established physical therapy modality used in orthopedics as an alternative treatment for osteoarthritis (OA). However, the precise cellular-level interventions and intrinsic mechanisms regulating the joint microenvironment remain poorly understood. In this study, we developed a near-infrared (NIR)-responsive nanotransducer composed of selenium-doped carbon quantum dots attached to black phosphorus nanosheets and coated with a membrane derived from M2 macrophages (M2M), termed M2M@BPSC. Upon NIR stimulation, M2M@BPSC selectively induced mild hyperthermia in macrophages, thereby inhibiting the transient receptor potential vanilloid type 4 (TRPV4) channel to inhibit calcium ion influx and prevent calcium overload-induced mitochondrial dysfunction. Furthermore, TRPV4 suppression promotes the nuclear translocation of signal transducer and activator of transcription 6 dimers, enhancing the transcriptional activity of early growth response 2. This activates the expression of M2-polarization-associated genes. Programmed M2M exerts bidirectional regulatory effects on both chondrocytes and fibroblast-like synoviocytes, thereby restoring the balance between cartilage extracellular matrix (C-ECM) degradation and fibrosis ECM (F-ECM) production. Overall, we identified a thermosensitive ion channel-targeting strategy that effectively modulates the pathological microenvironment in OA.

Indexed as

CalciumMacrophagesOsteoarthritisPhotothermal TherapyAnimalsCarbon Quantum DotsChondrocytesHumansMiceTRPV Cation ChannelsCalciumTRPV Cation Channelscalcium influxmacrophage polarizationosteoarthritisphotothermal therapytransient receptor potential vanilloid type 4

Identifiers

PMID41787915
PMCPMC13185896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.