Evidence map›Paper›PMID 41787840›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Real-Time Antifouling Multivalent Aptamer Platform for Wash-Free Electrochemical Detection of Low-Abundance Biomarkers in Human Plasma.

Payel Sen, Survanshu Saxena, Zijie Zhang, Navreen Sandhu, Pranati Das, Jimmy Gu, Todd Hoare, Yingfu Li, Leyla Soleymani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Payel SenDepartment of Engineering Physics, McMaster University, Hamilton, Canada.
Survanshu SaxenaSchool of Biomedical Engineering, McMaster University, Hamilton, Canada.
Zijie ZhangDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Navreen SandhuDepartment of Engineering Physics, McMaster University, Hamilton, Canada.
Pranati DasDepartment of Engineering Physics, McMaster University, Hamilton, Canada.
Jimmy GuDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Todd HoareSchool of Biomedical Engineering, McMaster University, Hamilton, Canada.
Yingfu LiSchool of Biomedical Engineering, McMaster University, Hamilton, Canada.ORCID 0000-0002-7533-6743
Leyla SoleymaniDepartment of Engineering Physics, McMaster University, Hamilton, Canada.ORCID 0000-0003-4915-2999

Funding

MITACS Accelerate Internship IT30008Natural Sciences and Engineering Research CouncilZentek Ltd.
6 · The paper itself

Abstract

Sensitive and specific detection of low-abundance proteins in complex biofluids is essential for early disease diagnosis and real-time health monitoring. Electrochemical aptamer-based biosensors offer rapid, point-of-care potential, but their clinical translation has been limited by biofouling, matrix variability, and signal instability in samples such as human plasma. Here, we introduce the Real-Time Magnetic Multivalent Aptamer (RT-MagMAp) assay, a one-pot, wash-free electrochemical platform that detects the low-abundance biomarker VEGF

Indexed as

Aptamers, NucleotideBiomarkersBiosensing TechniquesElectrochemical TechniquesVascular Endothelial Growth Factor AHumansAptamers, NucleotideBiomarkersVascular Endothelial Growth Factor AVEGFA protein, humanantifoulingaptamerselectrochemical biosensingprotein biosensingreal‐time sensing

Identifiers

PMID41787840
PMCPMC13080413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.