SynthesisWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Transcriptomics in Venous Leg Ulcers (VLU): A Systematic Review.
Synthesis in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Transcriptomics in Venous Leg Ulcers (VLU): A Systematic Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous leg ulcers (VLUs) are chronic wounds in the lower limbs that cause significant morbidity. The underlying biology underpinning non-healing in VLUs is still poorly understood and differences in transcriptomic profiles may help elucidate biological pathways involved in wound chronicity. A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Studies were included if transcriptomes from adults with confirmed VLU were described. A search of EMBASE, OVID and PubMed between 1 January 1994 and 17 August 2024 yielded 429 articles; 34 studies were included after full-text screening by two independent reviewers. Twenty-nine studies investigated coding messenger RNA (mRNA) expression, while five studies investigated non-coding RNA. Samples were obtained from wound biopsies (n = 31) or whole blood (n = 3). There were variations in mRNA expression across comparisons between patients with VLUs and controls such as tissue from other patients, tissue from different sites and treated tissues. Altered levels of mRNA transcripts suggest chronic inflammatory states, hyperproliferation and reduced wound healing. Studies exploring non-coding RNAs described their roles in regulating wound repair. Paired analyses of microRNA expression demonstrate impact on RNA expression profiles, with effects on inhibition of wound healing. Transcriptomic analysis provides new insights into the pathophysiology of the development and healing of VLUs. Further development of RNA biomarkers and gene expression profiles can improve diagnosis and prognostication of VLUs, but heterogeneity of current data may make it difficult to draw clinical significance. Trial Registration: PROSPERO: CRD42024580526.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.