Evidence map›Paper›PMID 41787678›Full record

ArticleGlia2026

The Ubiquitin Ligase Zinc Finger SWIM Domain-Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA-7 Axis.

Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing LeiInternational Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Siming ZhongZhejiang University-University of Edinburgh Institute, Zhejiang University, Haining, China.
Rong FanCollege of Life Science, Zhejiang University, Hangzhou, China.
Xin ShuZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Guan WangDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
Jiansheng GuoCenter of Cryo-Electron Microscopy, Zhejiang University, Hangzhou, China.ORCID 0000-0003-3459-4030
Shuting XueZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Luqian ZhengZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Aiming RenZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Junfang JiZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Bing YangZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Shumin DuanDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
Zhiping WangDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
Xing GuoZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Funding

National Key Research and Development Program of China 2016YFA0501000National Key Research and Development Program of China 2023YFF1204400National Natural Science Foundation of China 31671039National Natural Science Foundation of China 32071257
6 · The paper itself

Abstract

Proteostasis of proteins with intrinsically disordered regions (IDRs) is of particular importance to the development and function of the central nervous system (CNS). The conserved ZSWIM8 ubiquitin ligase, an essential regulator of mammalian brain development, is known to target IDR proteins involved in neuronal cell migration. Here we show that ZSWIM8 is also indispensable for oligodendrocyte maturation and myelination in the CNS. Loss of ZSWIM8 in the brain causes gross accumulation of IDR-rich proteins including many RNA-binding proteins (RBPs). Substrate recognition by ZSWIM8 requires its own IDRs, while ZSWIM8-mediated ubiquitination of AGO2 also depends on microRNA binding. AGO2 stabilization in ZSWIM8-null tissues disrupts target-directed microRNA degradation (TDMD) of MiR7, leading to altered gene expressions and myelination defects in vivo. Together, these results not only establish ZSWIM8 as a versatile regulator of IDR proteins but also highlight the crucial roles of RBP/miRNA homeostasis in oligodendrocyte development.

Indexed as

Argonaute ProteinsMicroRNAsOligodendrogliaUbiquitin-Protein LigasesAnimalsBrainGene Expression Regulation, DevelopmentalMiceMice, KnockoutMyelin SheathAgo2 protein, mouseArgonaute ProteinsMicroRNAsMIRN7 microRNA, mouseUbiquitin-Protein LigasesAGO2E3 ubiquitin ligaseELAV1intrinsically disordered regionMiR7myelinationoligodendrocyte developmentoligodendrocyte progenitor cellsZSWIM8

Identifiers

PMID41787678
PMCPMC12963713

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.