Observational studyPaediatric anaesthesia2026
EEG Dynamics in Children Before, During and After General Anesthesia.
Observational study in Paediatric anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02481999 (Pre- and Postoperative EEG-Monitoring for Children Aged From 0,5 to 8 Years), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre- and Postoperative EEG-Monitoring for Children Aged From 0,5 to 8 Years
Who cites it
1 citing paper in PubMed.
- EEG Dynamics in Children Before, During and After General Anesthesia.Paediatric anaesthesia · 2026Observational
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-specific EEG signatures during anesthesia are described in pediatrics, and perioperative monitoring is increasingly advocated; yet most indices and algorithms derive from adult data and may not generalize to early development.
aimsThe purpose of this study was to characterize perioperative frontal EEGs in young children younger than 8 years.
methodsA total of 147 frontal EEGs from children ranging from 1 month to 8 years of age were recorded prospectively under general anesthesia at Charité-Campus Virchow Klinik (CVK). For data acquisition, the Narcotrend Monitor was used, and the raw EEG files were further analyzed in their frequency bands. The patient cohort was divided into four age groups (0-5, 6-11, 12-23, and > 24 months), and EEG signatures were compared between the age groups.
resultsDelta activity is the predominant frequency in all age groups already in the awake state before induction of anesthesia, with a step increase at loss of consciousness, which is more pronounced in older children. Intraoperatively, alpha- and beta-activity emerge at the age of 6 months and are greater in the older age groups. Infants (0-5 months) remain with a high amount of Delta activity intraoperatively. With the return of consciousness, the faster frequencies gradually decrease, and the EEG is characterized again by a predominant delta-activity in all age groups.
conclusionsIn this study, we characterized differences in the perioperative EEG signatures of children from 1 month to 8 years from the preoperative awake state during induction and general anesthesia until they regained consciousness from general anesthesia. The EEG readouts differ across age groups, and age-adapted monitoring systems are needed to protect this vulnerable patient group from over- and undersedation.
trial registrationThis study was approved by the Charité-University Medicine Berlin's ethics committee (EA2/027/15) and was registered at clinicaltrials.gov (23rd of June 2015/NCT02481999).
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