Evidence map›Paper›PMID 41787580›Full record

ArticleGut pathogens2026

Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan.

Chiung-Ju Chen, Chiao-Yu Kao, Ya-Yu Cheng, Rong-Xuan Wu, Yen-Zhen Zhang, Daniel Yeng-Fong Lin, Ming-Cheng Wang, Wei-Hung Lin, Ching-Hao Teng, Hsu-Feng Lu and 6 more

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Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

16 authors.

Chiung-Ju ChenDepartment of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chiao-Yu KaoDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ya-Yu ChengInstitute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112304, Taiwan.
Rong-Xuan WuInstitute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112304, Taiwan.
Yen-Zhen ZhangInstitute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112304, Taiwan.
Daniel Yeng-Fong LinSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ming-Cheng WangDivision of Nephrology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Wei-Hung LinDivision of Nephrology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Ching-Hao TengInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsu-Feng LuDepartment of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan.
Yu-Tsung HuangDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Pei-Fang TsaiDepartment of Pathology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Ying-Chi LiDepartment of Pathology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Shih-Fen TsengDepartment of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, No.1492, Zhongshan Rd., Taoyuan Dist., 330, Taoyuan, Taiwan.
Li-Cheng YenDepartment of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, No.1492, Zhongshan Rd., Taoyuan Dist., 330, Taoyuan, Taiwan. terrsa0829@gmail.com.
Cheng-Yen KaoInstitute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112304, Taiwan. kaocy@nycu.edu.tw.

Funding

National Science and Technology Council 113-2740-B-A49-003-Shin Kong Wu Ho Su Memorial Hospital 2024SKHAND011Taoyuan General Hospital, Ministry of Health and Welfare PTH-114012Yen Tjing Ling Medical Foundation CI-113-029
6 · The paper itself

Abstract

backgroundKlebsiella pneumoniae, K. quasipneumoniae, and K. variicola are members of the K. pneumoniae species complex (KpSC) with distinct genotypes, virulence, and antibiotic resistance traits. However, their distribution and characteristics in Taiwan remain unknown.

methodsWe evaluated 809 KpSC isolates (377 from bacteremia and 432 from urinary tract infections) collected at National Cheng Kung University Hospital (NCKUH) (1999-2022), identified by multiplex PCR and 16S rDNA sequencing, and characterized by antimicrobial susceptibility testing, virulence gene profiling, capsular typing, biofilm assays, and Galleria mellonella larvae infection models.

resultsAmong the 809 KpSC isolates, 752 (93.0%) were identified as Klebsiella pneumoniae, 37 (4.6%) as K. quasipneumoniae, and 20 (2.4%) as K. variicola. MALDI-TOF was unable to identify any of the 37 K. quasipneumoniae isolates correctly, but it accurately identified 17 of the 20 K. variicola isolates. K62 was the most prevalent capsular type among K. pneumoniae isolates (7/50, 14%), while K54 was the most common among K. quasipneumoniae isolates (5/37, 13.5%). Among the 20 K. variicola isolates, K35 and K49 were the major capsular serotypes, each represented by three isolates (3/20, 15%). Notably, 16.8% of KpSC isolates could not be assigned to any serotype based on wzi sequencing. The prevalence of iucA, iroB, irp1, irp2,

conclusionK. pneumoniae, K. quasipneumoniae, and K. variicola in Taiwan exhibit distinct genotypic and phenotypic characteristics. K. quasipneumoniae and K. variicola displayed higher mortality in larvae infection model, underscoring the importance of continued surveillance of their dissemination.

Indexed as

Antibiotic resistanceKlebsiella pneumoniae species complexLarvae infectionMultiplex PCRVirulence genes

Identifiers

PMID41787580
PMCPMC13072495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.