ReviewCritical care (London, England)2026
The poikilothermic hypothesis of sepsis.
Review in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.Brain, behavior, & immunity - health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Accumulating evidence suggests that fever and hypothermia in sepsis may result from a state of minimally regulated body temperature, resembling the thermoregulatory patterns observed in cold-blooded animals (poikilothermia). Increasing data indicate that pharmacological agents capable of inducing poikilothermia, could offer therapeutic benefits, including enhanced survival and faster recovery in septic patients. This narrative review examines both experimental and clinical evidence supporting the poikilothermic hypothesis of sepsis and explores its potential clinical implications. We propose the poikilothermic hypothesis as a comprehensive framework to explain the diversity of thermal phenotypes observed in sepsis and to address ongoing therapeutic challenges. Furthermore, a deeper understanding of functional poikilothermia may ultimately enable personalized temperature management strategies for septic patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.