ArticleGenome biology2026
Augmented CENH3 loading is accompanied by transcriptional and epigenetic reprogramming at rice centromeres during meiosis.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundCentromere identity in eukaryotes is defined epigenetically by CENH3 (CENPA), a specialized histone H3 variant essential for kinetochore establishment and faithful chromosome segregation. However, the regulatory mechanisms governing CENH3 loading during meiosis and how they differ from mitotic patterns remain insufficiently elucidated.
resultsHere we characterize the dynamics of CENH3 deposition across meiosis and compare them with mitotic loading in rice. Quantitative fluorescence imaging reveals a pronounced increase of CENH3 signal during meiotic prophase I, coinciding with increased accumulation of multiple kinetochore components. Super-resolution stimulated emission depletion microscopy further confirms a distinct peak of CENH3 loading at zygotene. Through low-input ChIP-seq integrated with multi-omics profiling of purified meiocytes, we find that this meiosis-specific enrichment reflects both expanded and intensified CENH3 deposition, predominantly at Ty3-Gypsy retrotransposons. This remodeling is accompanied by reduced transcription of mRNAs and small RNAs, along with a reduction in CHG methylation and H3K9me2 heterochromatin marks.
conclusionOur findings uncover a previously unrecognized, meiotic-specific pattern of CENH3 loading in rice and highlight a coordinated regulatory network linking centromeric chromatin reorganization, transcriptional repression, and epigenetic modification during early meiotic progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.