Evidence map›Paper›PMID 41787385›Full record

ArticleBMC cancer2026

LncRNA EGFR-AS1 inhibits ferroptosis to reduce radiosensitivity of cervical cancer through the m6A/IGF2BP3/APAF1 axis.

Xianglong Chen, Jingyu Li, Yujie Sun, Zhaoyu Ye, Man Long, Junguo Bu, Zirong Fan, Zhaojing Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianglong Chen *Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Jingyu Li *Department of Radiotherapy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Yujie Sun *Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Zhaoyu YeDepartment of Radiotherapy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Man LongDepartment of Doppler Ultrasonic, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Junguo BuDepartment of Oncology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong Province, China.
Zirong FanDepartment of Radiotherapy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Zhaojing JiangDepartment of Radiotherapy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. jingjing@smu.edu.cn.

Funding

National Natural Science Foundation of China 82202930
6 · The paper itself

Abstract

backgroundCervical cancer is a significant concern among women, and radioresistance is a key obstacle in its treatment. Ferroptosis is a new way of death, which offers a fresh idea for tumor radiotherapy. We aimed to elucidate the mechanisms of lncRNA-mediated ferroptosis in radiosensitivity of cervical cancer.

methodsIn this study, TCGA database analysis was used to determine key lncRNAs associated with ferroptosis and radiosensitivity in cervical cancer. The function and mechanism of lncRNAs on ferroptosis and radiosensitivity was investigated by in vitro and in vivo.

resultsWe found that radiotherapy triggered cervical cancer cell ferroptosis and ferroptosis inducer inhibited the viability of radiotherapy-treated cervical cancer cells. Bioinformatics analysis identified EGFR-AS1 as a lncRNA associated with radiosensitivity and ferroptosis in cervical cancer. EGFR-AS1 was significantly increased in radiotherapy-treated cervical cancer cells and radioresistant tissues. Interfering with EGFR-AS1 expression induced ferroptosis of cervical cancer cells. Animal experiments revealed that EGFR-AS1 inhibits radiosensitivity in vivo. Mechanically, EGFR-AS1 bound to the m6A recognition protein IGF2BP3. Meanwhile, EGFR-AS1 was involved in the p53 signaling pathway and regulated APAF1 through IGF2BP3 and m6A modifications. Furthermore, EGFR-AS1 restrained ferroptosis in cervical cancer cells via the m6A/APAF1 axis.

conclusionsIn conclusion, this study revealed that EGFR-AS1 suppressed ferroptosis of cancer cells via the m6A/IGF2BP3/APAF1 axis, thereby decreasing radiosensitivity of cervical cancer. Our study offers fresh ideas for the radiosensitization mechanism of cervical cancer.

Indexed as

FerroptosisRadiation ToleranceRNA-Binding ProteinsRNA, Long NoncodingUterine Cervical NeoplasmsAnimalsCell Line, TumorErbB ReceptorsFemaleGene Expression Regulation, NeoplasticHumansMiceSignal TransductionXenograft Model Antitumor AssaysEGFR protein, humanErbB ReceptorsRNA-Binding ProteinsRNA, Long NoncodingCervical cancerFerroptosisLncRNA EGFR-AS1m6A modificationRadiosensitivity

Identifiers

PMID41787385
PMCPMC13072668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.