Anesthetic management of a patient with McCune-Albright syndrome complicated by pathological cervical fracture: a case report.

Zhenghui Li, Hongli Yue, Weihua Cui

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Article in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Zhenghui LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Hongli YueDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Weihua CuiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. weihuacui@ccmu.edu.cn.

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6 · The paper itself

Abstract

backgroundMcCune–Albright syndrome (MAS) is a rare sporadic disorder caused by post-zygotic activating mutations in GNAS, classically characterized by café-au-lait macules, endocrine hyperfunction, and fibrous dysplasia of bone (FD). MAS presents challenges in anesthetic management due to airway difficulties, cervical spine deformities, and bone lesions. CASE PRESENTATION: A 40-year-old female with a history of growth hormone-secreting macroadenoma, for which she underwent transsphenoidal resection, presented with a pathological cervical spine fracture. Enhanced cervical MRI showed destruction of high cervical vertebrae and multiple space-occupying lesions. Awake fiberoptic intubation was performed under sedation, followed by general anesthesia induction and maintenance with a balanced intravenous-inhalational technique.

conclusionThis case highlights the importance of preoperative airway assessment and the use of awake fiberoptic bronchoscopy for intubation in MAS patients, especially those with cervical spine lesions. Personalized anesthetic strategies are essential for optimizing patient safety.

Indexed as

Anesthesia, GeneralCervical VertebraeFibrous Dysplasia, PolyostoticFractures, SpontaneousSpinal FracturesAdultBronchoscopyFemaleFiber Optic TechnologyHumansIntubation, IntratrachealMagnetic Resonance ImagingCafé-au-lait spotsDifficult airwayDifficult tracheal intubationFibrous dysplasia (FD)Growth hormone-secreting pituitary macroadenoma/acromegalyMcCune-Albright syndrome

Identifiers

PMID41787301

DOI10.1186/s12871-026-03744-9

PMCPMC13077800

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.